Use of a T-cell interferon-γ release assay for the diagnosis of tuberculous pleurisy
نویسندگان
چکیده
1 Section of Respiratory Disease, Department of Oncology and Hematology, University of Modena and Reggio Emilia, Modena, Italy; Department of Pulmonary Diseases and Tuberculosis, Diakonessenhuis Utrecht, Utrecht, The Netherlands; 3 TB Reg. Ref. Centre, Villa Marelli, Niguarda Hospital, Milan, Italy; 4 Division of Clinical Infectious Diseases, Research Center Borstel, Germany; 5 Division of Immune-cell Analytics, Research Center Borstel, Germany; 6 Department of Medical Microbiology and Immunology, Diakonessenhuis Utrecht, Utrecht, The Netherlands; Emerging Bacterial Pathogen Unit, San Raffaele Hospital, Milan, Italy
منابع مشابه
Clinical Utility of Two Interferon-gamma Release Assays on Pleural Fluid for the Diagnosis of Tuberculous Pleurisy
BACKGROUND The release of interferon-gamma (IFN-γ) by T lymphocytes increases after rechallenge with Mycobacterium tuberculosis antigen, especially, at a localized site of tuberculosis (TB) infection. We aimed to compare the clincial efficacy of two commercial IFN-γ release assays from pleural fluid for the diagnosis in tuberculous pleurisy. METHODS We performed T-SPOT.TB and QuantiFERON-TB G...
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BACKGROUND AND OBJECTIVE The diagnosis of tuberculous pleurisy by analysis of pleural fluid using standard diagnostic tools is difficult. Recently, T-cell interferon-γ release assays (IGRA) have been introduced for the diagnosis of tuberculous pleurisy. The aim of the present meta-analysis was to establish the overall diagnostic accuracy of IGRA on both pleural fluid and peripheral blood, for d...
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The diagnosis of pulmonary tuberculosis and tuberculous pleurisy standard methods is difficult and slow. Now, high hopes to cells of T cells secreting interferon-gamma in response to antigens of Mycobacterium tuberculosis. Use of the immune response to TB diagnosis. A systematic review was performed of latest publications. Interferon-γ release assays (IGRA) on peripheral blood mononuclear cells...
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The purpose of the present study was to investigate the diagnostic value of T cells spot test (T-Spot TB) combined with interferon-γ (INF-γ) and interleukin-27 (IL-27) in tuberculous pleurisy. Sixty patients with tuberculous pleurisy (observation group) and 60 patients with non-tuberculous pleurisy (control group) were enrolled in this study. T-Spot TB was performed to detect the pleural effusi...
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